CRYSTAL: Well, we were casting the movie, I was cast before she was. So many terrific actresses came in — all really, to this day, very strong, terrific, present talents and very well known, all of whom we had a good thing. It was always, “Well, she could do it. She could do it. She’d be great. She’d be great.” And then Meg came in and we didn’t even read a scene, and we all knew it was her. It’s just one of those indefinable things that when we started talking we were them already, you know? And what was really interesting was Meg had auditioned for Throw Momma From the Train (1987), which was the movie I did before Harry and Sally, to play my girlfriend, and the same thing happened. It was right after she was in Top Gun, and she was so great in Top Gun. And she came in and Danny DeVito was directing the movie, and I said, “Well, God, it’s so natural.” And I said, “What was that? We weren’t even trying and it was just great.” And he didn’t cast her because he felt for that character he wanted that she was a tad young. And I’ve always wondered if Danny had cast her and she had played my girlfriend, would Rob [Reiner] have said, “Well, I just saw you do that. I want something fresh.” I don’t know. But the mystery of Meg and I was just — there was no mystery. We just hit it off.
KALING: You just hit it off…
CRYSTAL: It’s like a love at first sight. And I’ll tell you an interesting anecdote, and I’m sorry you weren’t there, because I know how much you love the movie.
KALING: Oh yes, we did an episode [of The Mindy Project] called “Harry & Sally,” and everyone loved it the most, and then the finale has to do a lot with it.
CRYSTAL: So, Monday Rob was honored at Lincoln Center–
KALING: I read about this, yes.
CRYSTAL: And Meg and I walked out on stage together for the first time as a couple in 25 years. We’ve rarely seen each other over time — once in a while, you know how that is. So, when Rob was being honored, we got in touch and we started e-mailing, and we talked on the phone a couple of times, [talking about] what we might want to say and what to stay away from and so on and so forth. Then she came over and we spent an hour together on Sunday, the day before the event, and it was like it had never stopped. We both went, “Isn’t this something?” We just fell into each other all over again.
CRYSTAL: My Burns and her Gracie, you know, it really was that all over again. It was just, I hate this word, but it was delicious. So then when we walked out on stage together to “It Had to Be You” — nobody had any idea we were together. They snuck her in and out of Lincoln Center.
KALING: Oh, my God, I would have passed out.
CRYSTAL: And we walked out and the people went crazy. And we got to the podium and we just started talking, told stories, overlapped each other, giggled with each other. Besides the audience loving it, I said to them, “For those of you who wanted a sequel all these years, well, this is it.” And then we walked offstage and there was a monitor backstage and it showed the New Year’s Eve scene — the last scene in the movie where I had that speech to her — and we just held hands and looked at it. And [my character is] telling her, “You’re the last person I want to talk to before I go to sleep at night…,” “…when you want the rest of your life to start right away” — you know, all of those great lines. And we just looked at each other and just smiled and hugged each other. It was, like, perfect. It was really perfect. So, it’s that undefinable kind of thing that you call “chemistry” that I call…it’s like a magic that happens. It’s kismet. It’s meant to be. And you don’t have that with a lot of people.
KALING: It’s incredible that it didn’t feel like any time had passed. That, to me, is really the most remarkable thing.
CRYSTAL: It was astounding. And really Rob, who put us together, really created happily ever after for people with this movie. You believe in happily ever after. That’s why there was no sequel. We talked about it with [writer] Nora [Ephron] on and off, and we said, “Why? What are you going to do?” You know, “Where do you go?” People want to believe they’re okay, then they’re fine. (…) SOURCE